Yohimbine is promoted for its fat-burning properties and benefits for male sexual dysfunction. Though yohimbine is effective, side effects may include anxiety, nervousness, and an elevated heart rate, and the reported dose of yohimbine in many supplement formulas doesn’t match the actual dose.
Some evidence supports the use of yohimbine as a natural way to improve symptoms of erectile dysfunction (ED) in men. While studies have questioned this claim, two meta-analyses concluded that yohimbine taken alone or alongside other therapies, including arginine and PDE-5 inhibitors, improves ED when compared to a placebo, though studies using combined yohimbine and PDE-5 inhibitors have only been conducted in animals.
Although it's often marketed as a fat-loss and performance-enhancing supplement for athletes, there's no evidence that yohimbine improves strength, increases muscle, or enhances physical performance. Yohimbine does seem to have a lipolytic effect (increases 'fat burning') and may improve body composition or cause regional fat loss when used as a topical ointment.
Dosages of 0.2mg/kg bodyweight have been successfully used to increase fat burning without significant implications on cardiovascular parameters like heart rate and blood pressure. This results in a dosage of:
14 mg for a 150lb person
18 mg for a 200lb person
22 mg for a 250lb person
Supplementation is most effective between meals or during short term fasting.
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