SS-31, a peptide that targets mitochondria, has received recognition for its potential therapeutic applications in various medical conditions.
SS-31 is composed of four amino acids: D-arginine, D-arginine, D-tyrosine, and L-2,6-dimethyltyrosine, which makes it resistant to enzymatic degradation.
The unique structure of SS-31 allows it to effectively penetrate cell membranes and accumulate within the mitochondria.
Once nestled within the mitochondria, SS-31 engages in a pivotal molecular dance with cardiolipin, a specialised lipid predominantly found within the inner mitochondrial membrane.
This interaction with cardiolipin forms the crux of SS-31’s therapeutic mechanism.
By stabilising cardiolipin and maintaining the integrity of the inner mitochondrial membrane, SS-31 plays a vital role in sustaining mitochondrial function.
This cascade of effects ultimately results in increased ATP production and a boost in cellular energy, which has the potential to underpin a host of therapeutic applications.
HOW DOES SS-31 WORK?
SS-31, through its interaction with cardiolipin on the inner mitochondrial membrane, effectively prevents cardiolipin oxidation, safeguards the integrity of the mitochondrial cristae membrane, and renews the supply of ATP.
SS-31’s mechanism of action is closely tied to its ability to interact with cardiolipin. Cardiolipin is a phospholipid that plays a vital role in maintaining the structural integrity of the inner mitochondrial membrane and is essential for several mitochondrial processes, including oxidative phosphorylation, electron transport chain function, and the regulation of reactive oxygen species (ROS) production.
When cardiolipin is in a disordered state, it can impair mitochondrial function, leading to a cascade of detrimental effects, such as increased oxidative stress and reduced ATP production. SS-31 acts as a cardiolipin stabiliser, preventing its disorganisation and maintaining the integrity of the inner mitochondrial membrane.
Furthermore, SS-31 has been found to scavenge ROS, which are harmful byproducts of mitochondrial respiration, protecting mitochondrial DNA and proteins from oxidative damage.
By reducing oxidative stress and stabilising cardiolipin, SS-31 promotes optimal mitochondrial function, ultimately leading to increased ATP production and cellular energy.
First, it stabilises cardiolipin, preserving the mitochondrial membrane’s integrity. A stable mitochondrial membrane plays a crucial role in reducing the activation of inflammatory pathways.
Second, SS-31’s ROS-scavenging abilities indirectly contribute to reducing inflammation by mitigating oxidative stress, a major driver of neuroinflammation. As a result, the peptide shields neurons from harmful inflammation, preserving their structural and functional integrity.
Oxidative stress is intricately tied to cognitive decline. In neurodegenerative diseases, excessive production of reactive oxygen species (ROS) and free radicals leads to oxidative damage to neural tissue, impairing synaptic plasticity and overall cognitive function.
SS-31’s role as a bio-regulator lies in its ability to optimize mitochondrial function. By stabilising cardiolipin, SS-31 ensures that the mitochondria can generate energy efficiently and maintain cellular homeostasis.
This long-term mitochondrial health can contribute to healthier ageing and an extended healthspan. As mitochondria are integral to numerous cellular processes, their preservation through SS-31’s actions can potentially slow down the ageing process and enhance the overall quality of life.
Protection Against Oxidative Stress. Oxidative stress, characterised by an imbalance between the production of ROS and the body’s ability to neutralise them, is a hallmark of numerous diseases and the ageing process. SS-31’s role in protecting against oxidative stress is multifaceted and pivotal for maintaining overall health.
Step into a realm of enhanced well-being with SS-31, a peptide boasting a spectrum of therapeutic benefits. Inspired by our science-backed article, you’re undoubtedly eager to explore the potential of Peptide Therapy for yourself.
Seize the opportunity to optimise your health by securing your peptides through a personalised consultation with Jessica, our Integrative and Functional Medicine practitioner with years of expertise in Peptide Therapy, Jessica is your partner in the pursuit of well-being.
