Product Name: MK-677
Alias: Ibutamoren
CAS NO.: 159634-47-6
Molecular Formula: C27H36N4O5S
Molecular Weight: 528.664
Purity: 98%+
Appearance: White Powder
Grade:Pharmaceutical Grade
Attention: MK677 is easily moisture in the summer, so please be sealed and stored in the refrigerator.
Ibutamoren (developmental code names MK-677, MK-0677) is a non-peptidic, potent, long-acting, orally-active, and selective agonist of the ghrelin receptor and a growth hormone secretagogue,mimicking the growth hormone (GH)-stimulating action of the endogenous hormone ghrelin.It has been demonstrated to increase the release of, and produces sustained increases in plasma levels of several hormones including GH and insulin-like growth factor 1 (IGF-1), but without affecting cortisol levels.It is currently under development as a potential treatment for reduced levels of these hormones, such as in children or elderly adults with growth hormone deficiency,and human studies have shown it to increase both muscle mass and bone mineral density,making it a promising therapy for the treatment of frailty in the elderly.It also alters metabolism of body fat and so may have application in the treatment of obesity.
MK-677 may be a therapeutic agent to help increase muscle mass. A decrease in circulating plasma levels of growth hormone, especially as you age, have been directly correlated with an increase in body fat and loss of lean body mass. Growth hormone is a lipolytic and acts to reduce and redistribute body fat, as well as increase protein synthesis.
Growth Hormone reduces abdominal visceral fat (AVF) in GH-deficient adults and abdominally obese, postmenopausal women, but not normal elderly subjects. Despite increasing GH levels, MK-677 did not affect AVF.
GH induces several mechanisms for better sleep. The somatotropic axis consisting of growth hormone (GH), insulin-like growth factors (IGF-I and -II), and their associated carrier proteins are intricately involved in normal sleep, as evidenced by the fact that hypothalamic growth hormone-releasing hormone (GHRH) has sleep promoting effects and pituitary growth hormone (GH) release is strongly associated with slow-wave sleep (SWS).
Just like with other SARMs, the half life of MK-677 is a robust 24 hours, so once a day dosing is all that is needed.
It is recommended taking MK-677 upon waking up, on an empty stomach before you eat breakfast, and 25 milligrams (mg) a day is the bread and butter dosage. Some users will go as low as 5mg, or as high as 50mg.
