SR-9009 (Stenabolic):

Beginner Dosing Guide:

• Week 1 to Week 4: Start with 10mg per day, split into two doses of 5mg in the morning and before bed.
• If possible, split the dose into 4 x 2.5mg throughout the day, spaced 4 hours apart.
• Week 5 to Week 8: Increase to 15mg per day and add an extra 5mg dose during midday.

Intermediate Dosing Guide:

• Week 1 to Week 4: Take 15mg per day, splitting the dose into morning, midday, and evening.
• If using raw powder, aim for four doses of 4mg spaced evenly apart.
• Week 5 to Week 6: Consider 20mg per day.
• Week 5 to Week 6: Advanced users can go up to 30mg per day.

Cardarine (GW-501516):

• As little as 10mg per day is effective for Cardarine.
• Dosages typically range from 10mg to 20mg per day.
• Short cycles (around 4 weeks) with lower dosages can still yield exceptional results.

Heart Health

Pre-clinical data shows, that Stenabolic could help repair tissue damage after myocardial infarction (heart attack). Mild or severe tissue damage occurs with restoration of blood flow after a period of ischemia or lack of oxygen, when a heart attack occurs. The inflammation from a heart attack leads to heart failure.

Circadian mechanisms are critical regulators of reperfusion injury. SR9009 has demonstrated that short term targeting of the Rev-ERB benefits long-term cardiac repair post-myocardial ischemia reperfusion in mice, promoting efficient repair, and reduced inflammation.

Exercise Capacity

Stenabolic is what’s called an exercise mimetic, or as some call it “exercise in a pill”. The unique properties of stenabolic, enhance or even substitute for the beneficial effects of physical exercise, by improving cardiovascular performance, as well as increasing mitochondria production, and energy metabolism. Physical exercise essentially remodels skeletal muscle, and adapts to physical stress, enhancing its ability to burn calories.

Pre-clinical animal studies show that activation of the Rev-erbα by SR9009 increases exercise capacity by increasing mitochondria in skeletal muscle. Rev-erbα is expressed at higher levels in oxidative muscles compared to glycolytic muscles and exercise can further induce its expression.

The physiological changes in are thought to be mediated and activated by the AMPK pathway. AMPK is an energy sensor that, when activated in certain tissues, has many beneficial effects on our bodies. It stimulates metabolism, improves insulin sensitivity, decreases inflammation, and improves muscle performance.

There’s a reason, why the World Anti-Doping Agency (WADA) has banned Stenabolic. The properties, show that it’s potential as an ergogenic aid could greatly enhance cardiovascular performance, exercise capacity, and induce fat burning effects, from increase energy metabolism and basal metabolic rate.

Tumor Suppression

Other investigational studies show that SR9009 may have a chemotherapeutic effect on Human Glioblastoma T98G cells. Glioblastoma multiforme is the most aggressive type of brain tumor.

Research suggests that Stenabolic, decreases reactive oxygen species (ROS), also known as oxidative stress, via free radicals, as well as significant reduction in cell viability with consequences on cell cycle progression and tumor cell viability.

The pharmacological modulation of the tumor-intrinsic clock by REV-ERB agonists severely affects cell metabolism and promotes cytotoxic effects on cancer cells.